Know Your Medicine: THCV

As entry to hashish widens and analysis into the medicinal results of its compounds expands, we’re studying there’s far more to the hashish plant than THC and CBD. One of probably the most fascinating cannabinoids in hashish is tetrahydrocannabivarin or THCV. Preliminary research present promising therapeutic results for various illnesses together with diabetes and Parkinson’s illness.

THCV outcomes from a totally different chemical pathway than THC. Geranyl pyrophosphate joins with divarinolic acid to make cannabigerovarin acid (CBGVA), which modifications to tetrahydrocannabivarin carboxylic acid (THCVA) when uncovered to the enzyme THCV. When THCVA is heated, it decarboxylates to THCV.

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Like different cannabinoids, THCV has biphasic results, which means it has differing results on the physique at totally different doses and blood focus ranges. At low doses, THCV is a impartial antagonist of the CB1 receptor, binding to the receptor with out inflicting any results; nevertheless, at this low dose, it blocks different compounds (like THC) from binding to the receptor. THCV can also be a CB2 agonist, binding to this receptor — which is usually situated within the immune system and intestine — giving anti-inflammatory and analgesic results.  

Research exhibits at greater doses, THCV has the other impact on the CB1 receptor, binding to it and activating it, which expectedly ought to trigger some psychoactivity. Interestingly, members in a research who acquired THCV have been unable to differentiate it from a placebo as they felt no intoxicating results. In the identical research, the themes reported that once they got each THC and THCV collectively, the consequences of THC have been weaker or much less intense.  

THCV is being investigated as an “anti-obesity and anti-type-2-diabetes” agent because it improved glucose intolerance and elevated insulin sensitivity in overweight mice. Additionally, the cannabinoid was proven to be a neuroprotective agent and relieved signs in an animal mannequin of Parkinson’s illness.  

Another animal research demonstrated that THCV might have potent anti-nausea results.

Anecdotally, sufferers who’ve tried THCV-rich strains report urge for food suppression, much less nervousness, fewer tremors, and ache aid. These strains are sometimes advisable to these struggling PTSD who need assist reducing nervousness with out turning into intoxicated.  

THCV is a secondary cannabinoid (THC and CBD being the first cannabinoids) and most hashish crops include very small quantities.  However, there are a selection of strains which have, on analytical testing, proven to include physiologically vital ranges of THCV. These strains embrace Black Beauty, Doug’s Varin, Durbin Poison, and Malawi Gold.

Sources:
Englund, Amir, et al. “The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial.” Journal of Psychopharmacology 30.2 (2016): 140-151.

Garcia, C., et al. “Symptom‐relieving and neuroprotective effects of the phytocannabinoid Δ9‐THCV in animal models of Parkinson’s disease.” British journal of pharmacology 163.7 (2011): 1495-1506.

Pertwee, Roger Guy, et al. “The psychoactive plant cannabinoid, Δ9‐tetrahydrocannabinol, is antagonized by Δ8‐and Δ9‐tetrahydrocannabivarin in mice in vivo.” British journal of pharmacology 150.5 (2007): 586-594.

Rock, Erin M., et al. “Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ9‐tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.” British journal of pharmacology 170.three (2013): 671-678.

Wargent, E. T., et al. “The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.” Nutrition & diabetes three.5 (2013): e68.





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